Lansoprazole as an uncommon cause of anaphylaxis: What to give next?
1Department of Emergency Medicine, Acibadem Hospital, Istanbul, Turkey
2Department of Emergency Medicine, Gulhane Training and Research Hospital, Ankara, Turkey
3Department of Gastroenterology, Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
4Department of Internal Medicine, Koc University Hospital, Istanbul, Turkey
2Department of Emergency Medicine, Gulhane Training and Research Hospital, Ankara, Turkey
3Department of Gastroenterology, Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
4Department of Internal Medicine, Koc University Hospital, Istanbul, Turkey
Northern Clinics of Istanbul 2019; 3(6): 315-316 PubMed ID: 31650123 PMCID: PMC6790933 DOI: 10.14744/nci.2018.36539
Abstract
Proton pump inhibitors (PPIs) are one of the most prescribed drugs worldwide. Anaphylactic reactions of PPIs are rare; however, several cases have been reported. Here, we report a rare case of anaphylaxis that occurred immediately following lansoprazole intake. Following the successful management in the emergency department, skin prick and oral controlled challenge tests were performed to evaluate cross-reactivity. Thereafter, lansoprazole was switched to pantoprazole, which was well tolerated. Skin prick and oral controlled challenge tests can be performed for determining the cross-reactivity of PPIs to prevent adverse reactions.
Keywords: Anaphylaxis, cross-reactivity; lansoprazole; proton pump inhibitors.